Multi-scale Analysis of Genomics Data
PhD or Postdoc, 4 years, Delft, The Netherlands

re-posted from, 25.06.2010


Delft University of Technology (TU Delft) is looking for candidates who have shown themselves to excel in one of the following (or related) fields: bioinformatics, (bio)statistics, machine vision, pattern recognition or computer science.
   The starting salary for a PhD is 2042 (max - 2612), for a Post-doc is 2977 gross per month.
   Benefits: a flexible work week, free high-speed Internet access from home, and the option of assembling a customised compensation and benefits package (the 'IKA').
This project aims to exploit scale-space theory for the analysis of high-throughput genomics data to delineate the complex interplay among biological elements of molecular processes that takes place in living systems. The notion of scale plays an important role in how we observe our environment. For instance, considering a tree from a distance of a light-year or a nanometre is meaningless, but would make sense at a distance of a few metres. Clearly, objects only exist as meaningful entities across a certain range of scales. In the field of machine vision, it has been argued that the only appropriate approach to this problem is to analyse data at all scales simultaneously. This has led to the scale-space theory, which provides a framework for multi-scale representation of images or other signals. We will explore scale-space representations of various sources of genomics data and investigate how we can employ these representations to benefit follow-up analyses, e.g. classification or interaction inference. The challenge will be to develop innovative methodologies that can exploit available genomics data at multiple scales simultaneously rather than at a single scale, and to explore possible applications of these methods using datasets generated at the Kluyver Centre for Genomics of Industrial Fermentation, the Netherlands Cancer Institute (NKI) and publicly available datasets.

Qualifications and experience

Candidates should be in the possession of an MSc degree (PhD for a Post-doc appointment) and are expected to be fluent in written and spoken English. Knowledge of molecular biology is an advantage. Candidates are expected to be interested in working at the boundaries of several research domains (computer science, bioinformatics, molecular biology), and with people from several institutes (Kluyver, NKI).

Interested applicants should e-mail to J. Eddini the application materials:
   a detailed CV including contact details of references;
   a course list with grades;
   a letter of application in which you explain both your interest the relevance of your skills and experience in the context of this research project.
When applying for this position, make sure to mention vacancy number EWI2010-15.
For more information, visit the Delft University of Technology job site and contact Jeroen de Ridder (phone: +31 (0)15-2783418).

Deadline: 16 July 2010.