PhD position, Montpellier
re-posted from bioinfo.fr, 25.06.2010
Studying lipid metabolism of Plasmodium is of great interest as
its normal functioning is essential for the survival of the parasite.
Targeting this metabolism with drugs represents a new pharmaceutical
approach against malaria. Plasmodium is well suited for systems biology
studies because during its life cycle this parasite activates a rare
diversity of metabolic pathways. Reconstructing synthesis pathways of
lipid metabolism in Plasmodium is crucial for understanding the biology
of this agent of disease.
The objective of this thesis is to develop a
methodology for constructing dynamic mixed metabolic and genetic
networks by using heterogeneous data. This methodology will be applied
to transcriptomic and metabolomic data in order to build a model for
lipid metabolism in Plasmodium. This model will be used for /in silico/
studies of the life cycle and of the defences against perturbations of
The PhD Student will join the new team “Biological Physics and
Systems Biology” in the lab
DIMNP (UMR 5235) in Montpellier. This team
develops physical, mathematical and computer science approaches for the
understanding of the functioning of biological systems. At the centre of
its approaches is the multi-scale modelling of the biological processes
by using statistical physics, dynamical systems and stochastic processes
Qualifications and experience
A candidate should be motivated by systems biology
and with strong background in mathematical modelling and computer
science. Sound knowledge in applied algebra, differential equations and
machine learning, and substantial proficiency in an object-oriented
language (e.g. Python, Java, C/C++, Matlab) are absolutely required.
Previous training in biology is an advantage.
To apply, please send an e-mail with a CV and the names of 3 referees to
Deadline: 2 July 2010.
Prof. Ovidiu Radulescu
DIMNP - UMR 5235 CNRS/UM1/UM2
Pl. E. Bataillon - Bat. 24
Universite de Montpellier 2, CP 107
34095 Montpellier Cedex 5, FRANCE